Determination of Aspirin tablets from different industrial drug companies available in Iraqi pharmaceutical market.
Abstract
Aspirin is commercially available in the form of tablets containing 100 mg for oral administration. Aspirin content of each tablet which is manufactured from different industrial sources companies (SDI, NDI, BAYER, PHARMALINE, RIVA and COCUKLARCIA) using high performance liquid chromatography (HPLC) with reversed-phase (ODS-C18) column at low wave length of Uv-visible detection (280 nm). An efficient procedure was used for preparation of aspirin samples. The aspirin was eluted for 5 minute at flow rate 2ml/min and temperature equal to 298 K°. The retention time of aspirin was observed at 3.8 minuet. The main absolute recovery of aspirin of all tablets was taken from different above companies were (102, 94, 94, 92, 90 and 88%) respectively. The assay showed good relationship between area under the peak (AUP) and aspirin content (p> 0.001). The Iraqi companies tablets produced an accurate content of ingredients aspirin in each tablet.
Metrics