Abstract

In this study, was to investigate the hypolipidemic effect of Apple-cure drug on the hypercholesterolemic-induced new Zealand white rabbits by feeding the animals with normal chow (diet) enriched with 1% cholesterol and 10% corn oil for one month was investigated. Animals with normal and hypercholesterolemic diets through out the study were used as negative (A) and positive (B) control respectively. Moreover, hypercholesterolemic rabbits were treated with two different medications as follow: animals of group (C) were treated with standard antihyperlipidemic drug, Atorvastatin(2mg/Kg/day), while the animals of group (D) were treated with apple-cure drug (3ml/Kg/day of apple-cure tablet solution) daily via oral route for 4 weeks. The results showed that there was no significant change in the body weights of hypercholesterolemic rabbits (B,C) groups but there was a high significant reduction (p <0.005) in the body weights of group (D) rabbits. Blood samples were collected at 0,1,2,3 and 4 weeks after treatment to investigate serum lipid profile. The daily administration of Apple-cure for hypercholesterolemic rabbits (group D) was led to a high significant reduction ( p < 0.005) in both total cholesterol and triglycerides and significant reduction (p<0.01) in the LDL-cholesterol levels, while same administration led to significant increasing (p<0.01) in the HDL-cholesterol levels. These results indicate that the Apple-cure drug have a strong hypolipidemic effect through improving the serum lipid profile by decreasing total cholesterol, triglycerides and LDL-cholesterol levels and by elevating HDL-cholesterol level and it may be of greatful value in the treatment of dyslipidemias.

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The article was added to IASJ on 2013-01-07

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