Immunoflourescent assessment of Herpes Simplex Virus (HSV) type 1 in oral lichen planus


Background: Oral lichen planus is one of the most common dermatological diseases presenting in the oral cavity.Hence, viral infection of the oral mucosa may be involved in the pathogenesis of oral lichen planus, Taking in toconsideration the oncogenic potential of HSV-1, this study aimed to assess the presence of Herpes Simplex Virustype one by direct immunoflourescent in oral lichen planus. This study aimed to assess the presence of HSV type1 bydirect immunofluorescent in histopathologically diagnosed OLPMaterial and Method: Twenty formalin fixed embedded tissue blocks of oral lichen planus with 2 Positive control caseswere taken from patients having infection with herpes labialis, US Biological herpes simplex virus-1 Glycoprotein C wasused for detection of HSV-1 Ag by direct immunofluorescence assayResults: One case of oral lichen planus showed positivity of HSV 1 with a non- statistical significance.Conclusion: The present study couldn’t find any correlation between HSV-1 positivity with clinical andhistopathological features of OLP