Relationship between Lipid per oxidation, Lepton and Lipid Profile in Iraqi Women with Preeclampsia


The present study was carried out on two groups of pregnant Iraqi women .Group one consisted of 45 preeclampsia 23 mild and 22 severe preeclampsia compared to second group consisted of 25 normotensive pregnant women .The two groups were with same age, body mass indices and gestational age. Serum lipid peroxidation marker malondialdehyde (MDA), lipid profile, leptin, total antioxidant capacity (TAO) and paraoxanse activity (PON) were measured. Mean systolic and diastolic blood pressure between preeclamptic and control group showed a marked difference (p<0.01) ranging from 154.67 ± 4.2 and 118.73 ± 3.7mmHg in severe preeclampsia, 135.3 ± 4.8 and 95.45 ± 4.2 mmHg in mild preeclampsia compared to 120.2 ± 1.88 and 70.50 ± 2.2 mmHg in control respectively . Serum MDA level was significantly higher in women with severe preeclampsia (3.51 ± 0.45 µmoles /dl) than mild preeclampsia (2.52 ± 0.14 µmoles /dl) compared with (0.92 ± 0.12 µmoles /dl) in control group, when adjusting to cholesterol, the peroxidation remained significantly increased MDA/Cholesterol ratio: 1.41 vs. 1.18 pmol/L.The serum triglycerides and cholesterol were higher in women with preeclampsia especially in the severe preeclampsia. Mean serum leptin level was significantly high (p<0.01) in all preeclamptic (76 ±5.3ng/ml), when compared with a control group (26 ± 3.3ng/ml and the value of serum leptin level was much higher in severe preeclamptics (76 ±5.3ng/ml) than in women with mild preeclampsia (42±4.1ng/ml). All the variables of the lipid profile of preeclamptic patients were found to be significantly elevated as compared to controls. The total lipid profile was also compared to the severity of preeclampsia and total cholesterol was found to be significantly raised (p <0.01) in severe preeclampsia when compared to mild. On correlating serum leptin with lipid profile again total cholesterol was found to be significantly high (p <0.05) in preeclamptic group compared to controls. A significant reduce in TAC status and in paraoxanse activity (PON) was noticed in severe and mild preeclampsia than control group .We conclude that hypercholesterolemia leads to excessive lipid peroxidation. Coexistent diminution in antioxidant activity leads to an imbalance between prooxidants and antioxidants, resulting in oxidative stress. Oxidative stress and elevated atherogenic index may contribute to atherogenicity in preeclampsia.