EFFECT OF BISPHENOL A ON THYROID, LIVER AND TESTICULAR FUNCTIONS IN ADULT MALE RATS

Abstract

This study was carried out in Veterinary Medicine College / University of Basrahto investigate the effect of Bisphenol A on thyroid, liver and testicular functions. Atotal of 24 adult male rats were randomly divided into four equal groups, six animalsin each group. Animal of group (1) served as control and received a daily oraladministration of corn oil throughout the experimental protocol. Animals of group 2,3 and 4 were administered orally 50,100 and 200 mg/kg body weight of BPArespectively dissolved in corn oil, the experiment extended for 30 days. The resultsof the present study showed a significant decrease in serum thyroxin (T4)concentration and a significant increase in serum aspartate aminotransferase ( AST)and alanine aminotransferase ( ALT) concentration in bisphenol A treated groups. Asignificant decrease in serum testosterone and LH concentrations in all BPA-treatedgroups compared with control. On other hand non significant decrease in serumconcentrations of FSH were observed in BPA-treated groups compared with control.A significant decrease in epididymal sperm count and sperms motility in all BPAtreated groups. However no significant differences were noted in sperms viabilitybetween all BPA treatment groups and control. Histopathological changes were foundin thyroid glands of male rats with different doses of BPA, also central vein dilation,enlarged nuclei, vacuolation of hepatocytes were observed in the liver of BPA treatedgroups and different degrees of histological changes include depression ofspermatogenesis, decrease of leydig cells in dose dependent manner were found intesticular tissues of BPA treated groups.