Synthesis and Characterization of Schiff Base Folic Acid Based Ligand and Its Complexes


D-mannose sugar was used to prepare [benzoic acid 6-formyl-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl ester] (compound A). The condensation reaction of folic acid with(compound A) resulted in the formation of new ligand [L]. These compounds werecharacterized by elemental analysis CHN, atomic absorption A.A, (FT-I.R.), (U.V.-Vis),TLC, E.S. mass (for electrospray), molar conductance, and melting point. The newtetradentate ligand [L], reacted with two moles of some selected metal ions and two moles of(2-aminophenol), (metal : ligand : 2-aminophenol) at reflux in water medium to give a seriesof new complexes of the general formula K2[M2(L)(HA)2] where M= Co(II), Ni(II), Cu(II) andCd(II). These complexes were characterized by elemental analyses [(C.H.N) and (A.A)], (FTI.R), (U.V-Vis.), molar conductance, 1H,13C-NMR, TLC and magnetic momentmeasurements. From the above data the proposed geometry about Co(II), Ni(II), Cu(II) and Cd(II),is tetrahedral structure. Biological activity of the lignd and its complexes was carried o