Synthesis, Characterization and Biological Activity Study of some New Thiazolidine Derivatives


The study included the preparation of compound 2,2'-(1,4-phenylene) dithiazolidine-4-carboxylic acid (T) which were prepared from the reaction of Terphthaldehyde with cysteine under slightly conditions, This reaction afforded product as a mixture of diastereomers, Cis-(2R,4R) and Trans-(2S,2R), which could not be separated, An equilibrium resulting from epimerization at C(2) occurs between two isomers, The Cis/Trans ratios were strongly dependent on the nature of the solvent.Thiazolidine(T) react with acetic anhydride for the preparation of compound 2,2'-(1,4-phenylene) bis (N-acetyl thiazolidine-4-carboxylic acid) (AT) and which represents reaction protection for a amine group, then reacts compound (AT) with some aromatic amines to obtaincompound thiazolidine-4-carboxylic amide. The new synthesized compound were identified by melting points and FT-IR,1HNMR, 13CNMR and Mass Spectrum. The biological activity of some preparation compound were studied against two types of bacteria one of them were gram negative (E.coil) and other were gram positive (S.aureus ) .