Lipid Profile Changes in Women in Reproductive Age Group Using Injectable Medroxypogesterone Acetate Contraception


To evaluate lipid profile changes in women of reproductiveage group using Depot Medroxyprogesterone Acetate contraceptive lasting for three months. A prospective study in Al- Imamein Al- Kadhemein medical city from July 2013 to January 2014. The study included a total of 40 healthy multi para women in reproductive age group, visiting family planning clinic in Al- Imamein Al- Kadhemein medical city seeking for contraception.Verbal consent obtained from participants. Baseline serum lipids wasassessed prior to the use of Depot Medroxyprogesterone Acetate and thenthree months after the use of injection in 10-12 hours fasting women.A detailed questionnaire was designed, to be fulfilled by each clientincluding; all relevant issues: age, general health history, obstetric and gynecological history, menstrual cycle and relevant medical diseases andprevious use of contraception.In this study there was significant increase in serum LDL (p value <0.001) and significant decrease in serum HDL (p value<0.001) after three months of depot-medroxyprogesterone acetate injections in comparison to pre-injection group. There was insignificant increase in serum cholesterol (p value >0.05) and no changes in serum triglyceride, also there was no significant changes in BMI three months after injections (p value> 0.05).Depot medroxy progesterone acetate used in women with reproductive age group as injectable contraception, can cause significant changes in lipid metabolism.