Relation of Follicular Fluid C-Reactive Protein Level to Intracytoplasmic Sperm Injection Outcome at Al-Najaf Fertility Centre

Abstract

C-reactive protein is a protein that act as a sensitive marker in inflammatory processes, rises following hormonal stimulation it may affect fertility and intracytoplasmic sperm injection (ICSI) outcome. this study aimed to measure follicular fluid proinflammatory mediator as C-reactive protein and their relation controlled ovarian hyperstimulation protocols and to interpret these findings according to the cause of subfertility and subfertility treatment outcome. This study was carried out on 110 subfertile women aged between 18-45year (30.01±6.02), referred to fertility clinic in Al-Sadder teaching hospital at AL-Najaf city who classified into four group according to the cause of subfertility, estradiol(E2) also measured on day of HCG and CRP were measured in follicular fluid collected on day of pickup using special ELISA kit then correlate the result to ICSI outcome. The Result of this study reported that the pregnancy rate was 34.55% for embryo transferred after 48-72 hours, there was non-significant increment in pregnant than non-pregnant women regarding FF-CRP (P>0.05), also non-significant difference in FF- CRP in subfertile women according to cause of subfertility(p=0.303), higher FF-CRP value were in ovulatory factor female. Regarding ICSI parameters, there was positive non-significant correlation between FF- CRP and embryo number, Grade I, Grade II, embryo transferred, fertilization rate. so conclusion of this study minimal increment in these inflammatory markers would aid and share in success ICSI outcome.