Estimation of IL-1 Beta and IL-18 Level in Sera and Seminal Plasma in Infertile Men in Baghdad


Background: To evaluate the role of Interlukin-1 beta(IL-1 beta) &Interlukin-18 (IL-18) concentration in sera and seminal plasma of patients compared to fertile men.Methods: Sixty Six male (infertile group), and 25 fertile male (control group).Patients and control group’s seminal plasma & sera were analyzed using ELISA technique to determine IL-1 beta and IL-18.Results: The mean of IL-1 beta levels in control group (normospermia) in sera and seminal plasma is (92.1 & 31.7) pg/mL, respectively, while the mean of IL-18 in control group (normospermia in sera & seminal plasma is (410.8& 141.3)pg/mL.Whereas, sera IL-1 beta in patients group is (13.2, 41.6 & 59.8), it is in seminal plasma (5.1, 13.9 & 22.4) pg/mL in azoospermia, oilgozoospermia, and asthenozoospermia, respectively.Sera IL-18 in patients group is (131.8, 267.3 & 226.6), while in seminal plasma it is (50.1, 92.7 & 81.8)pg/mL in azoospermia, oligozoospermia, and asthenozoospermia, respectively.Conclusion: The cytokines IL-1 beta & IL-18 may play an important role in pathogenesis of male factor infertility.