Relationship between Toxoplasma gondii and Autoimmune Disease in Aborted Women in Najaf Province

Abstract

background:Autoimmune diseases are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The pathogenic hypothesis comprises a complex interaction between genetic, environmental and hormonal factors. Aim of this study to assess the association between toxoplasmosis and some autoimmune diseases. Methods: A case-control study was conducted to estimate the association between toxoplasmosis and some of autoimmune disease including diabetes mellitus, rheumatoid arthritis and systemic lupus erythematosus. The present study was carried out on 48aborted women, and 21non-aborted women, all of these cases were limited to females only in the reproductive age (16-50 years).Toxo-IgM and Toxo-IgG antibodies were detected with (ELISA) (Human/ Germany) in both groups, and measure blood sugar, ACCP, and ANF.Results: The infections with toxoplasmosis were 5(17.9%) and 23(82.1%) among those with diabetes mellitus and rheumatoid arthritis disease respectively. However, none of the 8 women with SLE had toxoplasmosis, Furthermore; the results revealed that toxoplasmosis positive women were about 4.4 folds more likely to have RA. (OR= 4.4, P≤ 0.01). Conclusion: This research concludes that the primary or secondary infections with Toxoplasma gondii can mimicry immune response and make shift in the immune response to induce autoimmune disease.