Synthesis, Characterization and Microbial Study Via Some New Salbutamol'sDerivatives


During this work, some new medical salbutamol,s derivatives were prepared, characterized and
their biological activity was determined. A simple and efficient procedure for obtaining 4-(1-
oxoacetyl-2-tert-butylaminoethyl)-6-methanolyl phenol 2 (acetylated salbutamol 2) from a reaction
between acetic anhydride and 4-(1-hydroxy-2-tert-butylaminoethyl)-6-methanolyl phenol 1
(salbutamol 1) in an acidic medium was reported. A coupling reaction between the diazonium salts
of aniline derivatives with an acetylated salbutamol 2 gave the new corresponding azo derivatives
in the selective yields. These compounds were characterized by various physical techniques like:
FTIR spectra, UV-Visible spectra, determination of the total number of hydroxyl groups of an
acetylated salbutamol 2, melting point and the evaluation of microbial activity in vitro against Gram
+Ve, Gram -Ve bacteria and fungi. A potent antibacterial activity was noticed only for the following
2-(2¢,4¢-Dichloroazophenyl)-4-(1-oxoacetyl-2¢¢-tert-butylaminoethyl)-6-methanolyl phenol 3.
2-(2¢,3-Dimethylazophenyl)-4-(1-oxoacetyl-2¢¢-tert-butylaminoethyl)-6-methanolyl phenol 5.
phenol 6.