Construction of Membrane Selective Electrodes for determination of Mebeverine Hydrochloride Drug

Abstract

This research includes the determination of Mebeverine Hydrochloride (ME) drug by using potentiometric method.by construction of liquid membrane selective electrodes of Mebeverine Hydrochloride using Sodium tetraphenyl borate (NaTPB) and Phospho Molybdic acid (PMA) as active substance and TBP as aplasticizer and poly vinyl chloride (PVC) as matrix for all electrodes .The results showed that the slope of Mebeverine Hydrochloride electrodes that constructed from NaTPB and PMA were 29.7 mv/decade and 30.5 mv/decade at pH range between 4.5-6.5 respectively ,The linear range was from (10-5 10-1)M, detection limit 3.6001x10-7M and 6.1845x10-7 M, the response time was (14-78) Sec. and (20-65) Sec. and life time 30 and 34 days for Mebeverine Hydrochloride electrodes respectively.The research also includes measurement of the selectivity of electrodes in presence of interference, Kpot values were less than 1 for all ions.The Mebeverine Hydrochloride electrodes were applied for the determination of active ingredient in Mebeverine Hydrochloride pharmaceutical preparation (Samaptaline Tablets) using direct and standard addition methods