Physiological study of Haemostatic Disorder of Haemophilia Patients


The study included a total of 44 venous blood sample of male patients with Haemophilia collected at Albatol educational hospital / Baquba and child protection hospital / Baghdad for the period from January to April of 2012 to investigate the effect of Haemophilia on blood clotting time parameter: Prothrombine time (PT), activated Partial Thromboplastin time (aPTT) and FVIII activity, and to detect the type of Haemophilia.Statistical analysis showed no significant differences in (PT) of the patients when compared with normal value of the assay, this test reflects the efficiency and normal concentration of the extrinsic pathway clotting factors which made in liver, an indication that the cause of the disease may be due to a deficiency or dysfunction of the intrinsic pathway of the blood coagulation cascade. These results were confirmed by decreased values of the partial Thromboplastin time (aPTT) in patients when balanced with normal values of the measurement, which reflects decline in the effectiveness of the coagulation factors of the internal pathway of blood coagulation cascade which include the factors FVIII, FIX, FX, FXI and FXII.Factor VIII activity test revealed that most Haemophilial patients in the study have a significant decline in FVIII blood-clotting activity which was ranged between 0.46% - 30% of normal values of activity. Which indicate that all the patients in this study suffering of Haemophilia type A with different degree of severity, The disorder was sub typed to acute type in 77.78% (34 cases, FVIII level less than 1% of normal), 17.78% moderate (8 cases, FVIII level 1-5% of normal) and 4.44% of milled (2 cases, FVIII level more than 5% but less than 40% of normal).