Metalloproteinase-7 (MMP-7) and their clinical rel- evance in urinary bladder cancer


Background: metalloproteinase-7 (MMP-7) is produced by stromal cells and by tumor cells,and overexpressed in a variety of epithelial and mesenchymal tumors. The aim of this study was to assessthe association of MMP-7 with clinical-pathological factors and to evaluate its diagnostic value in patients with bladdercarcinoma.Methods: Expression of MMP-7 was evaluated in tumor tissues of 32 urinary bladder cancer cases and 30 control groupswere xed in formalin and embedded in paraf n blokes, then analyzedby in situ hybridization technique.Results: Expression of MMP-7was signi cantly higher in tumor compared to normal samples. The expression signi cantly associated with tumor grade and muscle invasion.Conclusion: MMP-7 may play an essential role in pathogenesis of bladder cancer. And may helpful to conventional diagnostic tools in malignancy as diagnosis.