Synthesis, spectral characterization and biological studies of the ligand type N2O4 Schiff- bases and their (Fe (II), Zn (II), Cd (II) and Hg (II)) complexes.


Abstract: This study aimed to synthesis and characterize hexadentate Schiff's base ligand with the general structure (H2L) containing nitrogen and oxygen donor atoms type (N2O4).The ligand (N,N)-bis-(salicylidine)-1,2-bis-(o-aminophenoxy) ethane (H2L) was prepared from the reaction of o-aminophenol with salicylaldehyde in an acidic medium and the precursor 2-(2-hydroxybenzylieneamino) phenol was obtained, this precursor was reacted with dichloroethane in alkali medium to obtain the ligand (H2L).The prepared ligand (H2L) is characterized by FT-IR,UV-Vis,1H-NMR spectra and. The ligand was reacted with some metal ions under reflux in methanol with (1:1) ratio gave complexes of the general formula [M (L)], Where: MII= Fe, Zn , Cd and Hg. These complexes were characterized by atomic absorption, chloride content, I.R, U.V-Vis spectra, molar conductivity, HPLC, melting point, and biological activity were tested for some complexes of this ligand .The molar conductance showed that, all complexes are non-electrolyte. According to all these measurements . The proposed structures for (H2L) complexes were an tetrahedral geometry for FeII , Zn II , CdII and HgII . Keywords: Schiff-base ligand; (N,N)-bis-(salicylidine)-1,2-bis-(o-aminophenoxy) ethane; structural and biological studies.