Abstract

In this paper new Schiff bases and tetrazole derivatives of 2-Amino-1,3,4-thiadiazole- 5-thiol have been prepared.2-Amino-1,3,4-thiadiazole-5-thiol was prepared by the reaction of thiosemicarbazide with carbon disulfide in alcoholic sodium carbonate solution .The new Schiff bases derivatives [2_5] were prepared by condensation of aldehyde group with 2-Amino-1,3,4-thiadiazole-5-thiol (P-Nitrobenzeldehyde ,M- Nitrobenzeldehyde, P-Hydroxybenzeldehyde, , 4-Hydroxy 3-Methoxy benzeldehyde) . The resulting Shiffbase were Reaction with acetic anhydride [6-9] and this derivatives reaction with urea and thiourea intetrahydrofuran{10-17}. All new synthesized derivatives were identified by their melting points, and FT-IR,U.V spectra. Some products were identified in elemental analysis and Chledal analysis .They have long been known to possess hypnotics activities and it is hoped that our compounds would do so.

Keywords

The article was added to IASJ on 2016-11-05

564 Total full text downloads since the date of addition