Expression of CD44 in Saliva among Group of Smoker Patients with Oral Squamous Cell Carcinoma


The (CD44) biomarker is considered as one candidate molecular marker for detection of head and neck squamous cell carcinoma, it islisted as adhesion molecules. This protein has many functions and considered as multistructural cell surface protein which involved different pathological events. The over-expression of CD44 wasdetected in different cancers in human, including oral squamous cell carcinoma (OSCC). Therefore this study designed to evaluate the role of CD44 in OSCC, quantified in stimulated saliva, beside its correlation with smoking.This case-control study composed of 30 patients with oral squamous cell carcinoma who were smokers, and other 60 control persons for comparison: 30 subjects of them were smoking and others were free of smoking. CD44 was assessed by ELISA technique, in stimulated saliva collected from all groups.The result of this study show thatsalivary CD44 protein level significantly higher in smoker patients with oral squamous cell carcinoma in comparism to smoker and non-smoker control healthy persons, thus the CD44 protein have an important role, as a non-invasive way, in the early diagnosis and monitoring of oral squamous cell carcinoma patients.


OSCC, CD44, saliva, smoking