Preparation of Poly (N-4-Antipyrinyl or Procainyl Methyl Nadamic Acids) as Drug Polymers


Two new monomers of N-4-antipyrinyl methyl nadamic acid M1 and N-Procaienyl methyl nadamic acid M2 were synthesized from reaction of 4-Aminoantipyrine or procaine with methyl nadic anhydride at room temperature with dioxane as a solvent. The prepared monomers M1 and M2 were polymerized free radically with AIBN as initiator to corresponding polyamic acids P1 and P2, which were converted to their sodium salt polymers P3 and P4 to enhanced their solubility's in water. The physical and chemical properties were studied for monomers and polymers, also FT-IR, 1H-NMR and UV. Spectroscopy was characterized of M1or M2. The intrinsic viscosity was measured by Ostwald viscometer at 30 0C .The swelling % was measured and the controlled release rates of drug polymers were studied in different pH values at 37 0C.