Immunohistochemical expression of Cyclin D1 in mucoepidermoid and adenoid cystic carcinoma of the salivary glands


Background: Cyclin D1 proto-oncogene is an important regulator of (G1 to S) phase progression in many differentcell types. The Aims of this study were to evaluate the immunohistochemical expression of Cyclin D1 inmucoepidermoid and adenoid cystic carcinoma of the salivary glands and to correlate the immunoexpression ofthis protein with the clinicopathological findings.Materials and methodsRetrospectively, twelve of archival formalin fixed paraffin embedded tissue samples of salivary Mucoepidermoid andfourteen blocks of adenoid cystic carcinomas obtained from the archives of the department of oral pathology /college of dentistry / Baghdad university, Al-Shaheed Ghazi hospital, were included in this study. Five micrometersections obtained and immunostained using monoclonal antibody against Cyclin D1. The immunoexpression wasdetected by the presence of brown stain in the nucleus of tumor cell. The proportion of cells that expressed the stainwas correlated with the clinicopathological data of the patients.Results: Cyclin D1 expression was found positive in all cases of MEC and AdCC localized in tumor cells. Nonsignificantstatistical relation (p=0.588) was detected regarding Cyclin D1 expression in both types of tumor.Significant relation was found with stage of AdCC (p=0.04) and non-significant concerning other clinicopathologicalparameters in both tumor types.Conclusion: Weak expression of Cyclin D1 in MEC and AdCC might be explained by Cyclin D1 does not represent anexclusive factor consequently; other factors might be involved in the proliferation, progression and metastasis of bothtumor types.