An Evaluation of Serum and Salivary Adipokines (Leptin and Resistin) Levels in Periodontal Health and Disease


Background: With the start of the current century, increased the interest in the role of the adipose tissue derivedsubstances that named adipokines in the inflammatory diseases of the human being including the inflammatoryperiodontal disease, but scientific evidences were not clearly demonstrate the association between theseadipokines and periodontal pathologies.Materials and Methods: Forty two subjects male only with normal body mass index were selected for the study withan age ranged (30-39 years). Samples were divided into three groups of 14 subjects in each group based on clinicalperiodontal parameters; clinically healthy gingiva (group I), gingivitis group (group II) and chronic periodontitispatients group (group III), from whom saliva and serum samples were collected for estimating the levels of leptin andresistin using Enzyme-Linked Immuno Sorbent Assay (ELISA).Results: The results showed that the serum level of leptin and resistin were significantly higher in chronic periodontitispatient (9.81 ng/ml, 6.55 ng/ml) respectively as compared to gingivitis and healthy control groups (leptin; 8.10 ng/ml,ng/ml, resistin; 5.85 ng/ml, 5.45 ng/ml) respectively. On the other hand the level of leptin in saliva of patients withchronic periodontitis (0.17 ng/ml) was significantly lower than that of its salivary levels in gingivitis and healthy controlgroups (0.21 ng/ml, 0.29 ng/ml) respectively. Whereas, salivary resistin levels was significantly higher in chronicperiodontitis patient(14.45 ng/ml) when compared to the gingivitis group (11.59 ng/ml) and the health control group(6.43 ng/ml).Conclusions: Concomitant raise in serum leptin, serum resistin and salivary resistin, while a sensible reduction insalivary leptin with conversion from periodontal health state to periodontal disease state. These finding may draw asuggestion on the role of leptin and resistin in the relation between periodontal disease and the systemic health sincethe increase in their level were associated with a various systemic pathologies