Antinociceptive Effect of Peppermint in Mice

Abstract

background: Menthol the primary component of the essential oil of peppermint is thought to be responsible for most. of its properties. It is thought to provide. a local anesthetic action and be of use in musculoskeletal pain, but with no. experimental evidence for analgesic activity with respect to the. leaves of this plant.Methods: Forty Swiss mice of either. sex (weighing 20-25grams) was used in this study, divided into five. groups each with eight animals. Group 1: receiving distilled water. Groups 2, 3&4: pre-treated. with aqueous extract of peppermint in doses 50, 75 and 100 mg/kg, orally. Respectively, and Group 5: pre-treated with .standard drug (Ibuprofen 100 mg/kg), orally. The analgesic activity. was determined by radiant heat Tail-flick method in mice and converted (using special equation) to maximum. possible effect. The results are reported as mean ± S.E.M and analyzed with ANOVA followed by Dunetts multiple comparison test. The results. were significant at p<0.05.Results: The Maximal. Possible Effect (%MPE) was significant when peppermint was. used in a dose of 100mg/kg, and not significant when was used in doses of 50mg/kg &75mg/kg as compared. to % MPE of Ibuprofen.Conclusion: Peppermint has. analgesic effect when given orally as aqueous extract of dried leaves. in a dose of 100mg/kg in mice.