Histological Study Effects of Paracetamol on Livers and Kidneys of Adult Mice

Abstract

Background: paracetamol is an atypical opioid with monoamine re-uptake inhibition properties. Aim of work: This study was examined the histological changes in liver and kidney after administration of paracetamol-induced mice .Materials and methods: The study was conducted on 10 adult male mice. Mice were divided evenly into two groups: control group, received 1 ml normal saline 0.9% Treated group received ( 0.5 )ml of paracetamol/ body weight intra-peritoneally for 30 days. Results: The histological analysis of the liver showed that the thickening wall with minimal fibrosis in the periportal area infiltration of inflammatory cells in necrotic change of the hepatocytes massive vacoulation of the hepatocyte, kupffer cell were present intensity in the sinusoid. The histopathological examination of kidney revealed lymphocyte infiltration , congestion ,glomerulus and tubular damage. The tubular was containing hypertrophied epithelial cell which block the lumen . Conclusion: The histopathological alterations of liver, and kidney tissues threw lights on the possible risks of increased hepatic, renal and neurological damages evoked by repeated administration of paracetamol for long periods.