Study the Effects of Ginger (Zingiber officinale) Extract on Serum Lipid in Hypothyroidism Male Rats Induce by Propylthiouracil

Abstract

This study was undertaken to investigate the protective role of Ginger against the hypothyroidism induce by Propylthiouracil in male rats on serum lipids. Eighteen adult male rats were randomly divided into three equal groups (each of six) and treated as follows for four weeks, First group (C) was daily orally gavages with saline solution served as control.. Second group (G1) was daily orally gavages with Propylthiouracil (6 mg/kg B.W.). Third group (G2) was daily orally gavages with Propylthiouracil (6 mg/kg B.W.) in addition to ginger (200 mg/kg B.W.) Overnight fasting blood samples were collected from the all animals of the experiment at end week of experiment for the determination of serum triiodothyonine (T3), thyroid stimulation hormone (TSH), total cholesterol (TC), triacylglycerol (TAG), very low density lipoprotein-cholesterol (VLDL-C) and high density lipoprotein-cholesterol (HDL-C). The results showed that the A significant (P<0.05) statistical increase in the activity of TSH was observed in propylthiouracil treated groups G1 (3.72±0.73) and G2 (3.28±0.25) as compared to the control (0.0795±0.003) and A significant (P<0.05) statistical decrease in the activity of T3 in treated (G1) (2.62±0.2) as compared to the control (3.92±0.08). As well as the results show, a significant(P<0.05) elevation in serum TAG, TC and VLDL-C and decrease in HDL-C were observed in animals daily orally gavages with Propylthiouracil 6 mg/kg B.W. (G1) group as compared with control. Oral administration of ginger extract caused a non significant (P>0.05) depression in the elevated TAG and VLDL-C concentration in G2 group compared to G1 and control groups . From these results indicating that the effect of orally administration of propylthiouracil to induced hypothyroidism and induction of Dyslipidemia. On conclusions, the present study confirmed the beneficial effects of ginger extract as a hypolipidemic effects gains the dyslipidemia due to hypothyroidism.