Relation Between Plasma Levels of Vitamins C and E Antioxidents with Sociodemographic Factors During Pregnancy

Abstract

Background: Normal pregnancy induces profound changes in maternal physiology which promotes oxidative stress. Vitamins C and E are antioxidants that work as a defense against this oxidation process.Objective: To assess the plasma levels of the vitamins C and E at different trimesters of pregnancy and to correlate them with the sociodemographic factors of pregnant women.Method: A case control study had been conducted in Al-Kadhymia Teaching Hospital which enrolled 120 women. Ninety pregnant cases of 20 -40 years, 30 cases for each of the first, second and third trimesters were the study group and the control group were thirty cases of non-pregnant women of the same age group. Plasma level of vitamin C and E were estimated using high performance liquid chromatography (HPLC)method.Results: The plasma level of vitamin C was significantly different across the different trimesters of pregnancy and it was significantly lower than the control group P<0.001. Also the plasma level of vitamin C was significantly decreasing with increased parity and age P<0.05, and its level was higher in working pregnant women compared to the pregnant housewives. The plasma level of vitamin E was significantly decreasing through the three trimesters of pregnancy P<0.05.Conclusion: The plasma level of both vitamins C and E are reduced during pregnancy and life style and occupation have great impact on vitamin C level in plasma. There is significant declining in plasma vitamin C level with parity and increase in maternal age.