Serum Erythropoietin Concentration In Normal And Preeclamptic Pregnancies


Background: Preeclampsia is a multisystem disease and a threat to the well-being of both the mother and her newborn; it contributes significantly to the causes of maternal and perinatal morbidity and mortality. An increase in maternal plasma of erythropoietin in women with preeclampsia may be of placental origion and a reflection of an underlying placental hypoxic condition. Aims: To compare serum erythropoietin concentrations among patients with and without preeclampsia and to investigate the association between serum erythropoietin levels and preeclampsia.Methods: This case-control study involved one hundred pregnant women in their third trimester of singleton pregnancy with gestational age (28-40wk). Fifty patients were with preeclampsia (study group) and fifty patients were with normal healthy pregnancies (control group). For both groups maternal blood samples were collected for Erythropoietin concentration measured by ELISA method. Statistical analysis was performed to compare maternal serum erythropoietin levels in preeclamptic women and normal heathy pregnant women, and to evaluate the association between serum erythropoietin and preeclampsia. Results: Mean erythropoietin level for the preeclamptic group was (41.66±26.76) ranging from 10.716-159.121(mIU/ml) with a median of 36.101 mIU/ml, while for the control group, the mean value was (28.71±14.38) ranging from 6.482-65.228 (mIU/ml) with a median of 26.741 mIU/ml. Erythropoietin levels were significantly (P=0.003) higher among preeclamptic patients compared with controls.Conclusion: Women with preeclampsia have significantly higher levels of serum erythropoietin compared to normal healthy pregnancy.