Comparative study of the carnitine, Gensing, Dill, and Arginine effect in MDA, SOD, GSH levels in albino rats exposued to oxidative stress

Abstract

The aim of this study is to compare the effects of Carnitine, Gensing, Dill and Arginine in lipid peroxidation MDA and SOD, GSH antioxidant in normal and experimentally hydrogen peroxide H2O2 induced oxidative. Fifty male rats used in age 12-14 weeks in weights (300-325 g) divided randomly into 10 groups, included 5 in each group as following.Control, H2O2 , Carnitine , carnitine + H2O2 , Gensing , Gensing + H2O2 , Dill, Dill+ H2O2 ,Arginine , Arginine + H2O2 groups.Results showed:1-Treating normal rats with Carnitine, Gensing, Dill, Arginine, led to a significant increase (P≤0.05) in GSH level in all groups except Gensing group, and a significant decrease in MDA level in all groups except Carnitine group and no difference in SOD comparing to control group.2-Oxidative stress Induced by H2O2 led to significant increase in value (P≤ 0.05) in levels of MDA, comparing to control group. While there were a significant decrease in value (P≤0.05) in GSH, SOD.3-Treating rats exposure to oxidative stress with Carnitine, Gensing, Dill, Arginine, led to a significant decrease in value(P≤0.05) in MDA, While the treatment led to significant increase in GSH, , SOD comparing with H2O2 group.