Effect of Cefotaxime Administration on the kidney, liver and Lung of Swiss white Mice (mus musculus)


The present study was designed to monitor the impact a drug such as cefotaxime has on the histological architecture of the kidney, liver and Lung on Swiss white mice.The experiment was designed by using 30 Swiss white mice from both sexes.-Mice were classified randomly into three groups:Group A: Control Group, injected intramuscularly with 0.5ml distilled water daily for 6 days.Group B: Therapeutical Dose, Injected intramuscularly with 0.1 ml cefotaxime daily for 6 days.Group C: Extra Therapeutical Dose, Injected with 0.2 ml cefotaxime daily for 6 days.At the end of the experimental period, the kidney, liver and lung of the mice were taken and processed for histological study.The behavioral results showed a lower appetite and decrease in weight in the mice present in Group C.Histologically,the kidney and liver showed numerous abnormalities at the end of the treatment period compared to that of the control group.Pyknosis, Karyohyxis and Karyolysis were found in the liver cell nuclei. While infiltration of the lymphocytes was present. Necrosis of the hepatocytes were observed clearly throughout the tissue present in the lung.Renal convoluted tubules show atrophy and necrosis of cell with hypertrophy of glomeruli.Degeneration and shrinkage of the renal tubule cells with the appearance of pyknosis of nuclei was also found.Due to these destructive results on the liver and kidney cells it was concluded that cefotaxime caused many cell abnormalities and dysfunction in general.