Effect of using Melatonin in reducing the heart toxicity produced from the use of Doxorubicin drug on some hormones in the experimental male rabbits

Abstract

This study amid to search the role of Melatonin in reducing the heart toxicity and atherosclerosis which result from using of Doxorubicin in treatment of cancer Also the role of hydrogen peroxide in inducing oxidative stress in Laboratory Albino rabbit; Growth Hormone and (T3,T4,TSH) levels. the Study included 40 male rabbits, where each group consist of 5 animals. the study showed high Significant decrease in Growth Hormone concentration (P≤0.01) in Dox group (15mg/kg of.w) and group of animals treated with H2O2 alone while the concentrations of Growth Hormone had been increase with high significant (P≤0.01) in other groups. The results showed high significant (P≤0.01) in the hormone (T4) concentration in serum in the group H2O2 and Dox group alone compare with control and the occurrence of a highly significant increase (P≤0.01)of Hormone (T3) (T4) concentrations in Animal group treated with Dox (15 mg/kg) and Melatonin Also group treated with H2O2 and Melatonin, and group treated with Cholesterol and Melatonin. while high significant decrease (P≤0.01) had been happened in Hormone (T3) (T4) concentration in sera of other groups of animals compared with the control. and the results showed high significant (P≤0.01) in the hormone TSH concentration in serum in the group Dox and Cholesterol group alone compare with control. there were no significant differences in the concentration of the hormone TSH in the group H2O2 alone and the other groups compared with the control.