تحضير وتقييم الفعالية الحيوية لبعض معوضات البيرازول الجديدة المشتقة من 3- استيل كومارين

Abstract

This work includes synthesis of a number of coumarin derivatives containing pyrazole ring substituted . Where it was preparation chalcone compound [5] through reaction of 3-acetyl coumarin with terephthaldehyde at presence Piperidine as a catalyst . Chalcone was reactance with phenyl hydrazine and its derivatives to produce new derivatives of coumarin. The biological activity was evaluated for prepared compounds against some types of bacteria and fungus. Some compounds showed good inhibition results. The structural formulas of new synthetic compounds was charactered by analysis of the elements, the spectra infrared (FT-IR) and nuclear magnetic resonance of the (1H-NMR and 13C-NMR ), in addition to various physical available means