Formulation and evaluation of clarithromycim oral microspong

Abstract

Clarithromycin is a broad-spectrum antibiotic and extensively absorbed orally. It is be used in theeradication of H. Pylori infection combined with an acid suppressing agent. The purpose of this studywas to develop controlled release clarithromycin floating micro sponges for gastro retentive drugdelivery. The micro sponge’s formulations were prepared by quasi-emulsion solvent diffusionmethod employing eudragit RS 100 as a polymer and poly vinyl alcohol (PVA) as a surfactant.The compatibility of the drug with formulation components was established by FourierTransform Infra-Red (FTIR) spectroscopy. The prepared microsponge were evaluated for angleof repose, Carr's Index ,particle size, floating time production yield, drug loading efficiency ofmicro sponges. Shape and surface morphology of the micro sponges were been examined usingscanning electron microscopy. formulation F5 with drug to polymer ratio 8:1,10 ml of internalphase volume (ethanol: dichloromethane) and 0.25%pva solution was the best formulashowing the highest degree of sustained release that is 79.59% at the end of 12 hours withfloating time for 12 hr. Eudragit RS 100 could control drug release in stomach.