Estimation of Aromatase Enzyme in Obese Infertile Men

Abstract

Background: Male obesity is associated with physiological changes that can negatively affect male fertility. Obese men have demonstrated a 3-fold increase in the prevalence of oligozoospermia when compared with men with normal Body Mass Index (BMI). Objective: To estimate the role of aromatase enzyme in decreasing sperm parameters in obese infertile men. Subjects, Materials and Methods: Seventy obese infertile male (patients) and twenty obese fertile male (control) are enrolled in this study. Seminal fluid analysis done according to criteria of WHO (2010). Results: A significant negative correlation was found between human cytochrome enzyme and sperm concentration, progressively motile sperm, non-progressively motile sperm, immotile sperm and normal morphology.Conclusion:The present study showed clearly that male obesity negatively impacts fertilitythrough direct association between increased (BMI) and semen parameters. Theresults suggest that increased estrogen as a result of aromatization in the fattytissue, reflected through the increase in human cytochrome enzyme (aromatase),may be an important mechanism for the hypoandrogenemia and altered spermparameters