Synthesis Of Several New Cyclic Imides Linked To [3-Mercapto-5-(4ʹ-tolyl)-1,2,4-triazole]Moiety With Antibacterial Activity Study


In this work a variety of new cyclic imides containing1,2,4-triazole ringwere synthesized via multisteps synthesis.In the first step,p-toluic acid was introducedin esterification reaction with ethanol,producing compound[1]ethyl-4-methylbenzoate.Introducing of compound [1]in reaction with hydrazine hydrate in thesecond step afforded compound[2]4-tolyl acetohydrazide.Reaction of compound[2]with carbon disulfide in alkaline medium followed by refluxing the product withhydrazine hydrate afforded compound[3]3-mercapto-4-amino-5-(4ʹ-tolyl)-1,2,4-triazole.Compound [3]was introduced in reaction with different cyclic anhydridesproducing a series of new amic acids[4-8]which subsequently were dehydrated viatreatment with acetic anhydride and anhydrous sodium acetate producing thecorresponding target imides [9-13]. Antibacterial activity study of the new imidesindicated that,they exhibit good inhibition activity againt the tested organisms.