Synthesis of N- Drug MaleamideChitosan Drug polymers


In this research a new prodrug chitosan maleamide derivatives weresynthesis via reaction of amino group of chitosan with maleic anhydride thenconverted to its corresponding acyl chloride, of the chitosan maleatederivative (A1) was reacted with different drug-NH2 (A2-A5) such asprocaine, cephalexin, amoxicillin, and 4-aminoantipyrine.which could havepotential use as a natural drug delivery system as a sustain release throughhydrolysis of amide attachment in different pH values such as in acidic orbasic medium. These derivatives were characterized by FTIR and 1H-NMRspectroscopies. Controlled drug release was studied using UV. Spectroscopyat λmax 270nm gave a constant swelling percentage were measured indicatedcontrolling release with other advantages and to minimize the toxicity and theside effect. Thermal analysis such as TGA and DSC were studied indicatedthe thermally stableprodrug polymers.