Formulation &invitro evaluation of clarithromycin floating microsponge capsule


Objective: The aim of this study is to formulate microsponge of clarithromycin capsuledosage form and evaluate the release profile in comparing with marketed clarithromycin(Clamycin)Methods: clarithromycin microsponge was prepared by quasi-emulsion solvent diffusionmethod by using polymers Eudragite RL100 in organic solution as internal phase andaqueous solution of polyvinyl alcohol as external phase. The compatibility of the drugwith formulated components was established by Fourier Transform Infra-Red (FTIR)spectroscopy. The prepared microsponge powder was evaluated for angle of repose,Carr's Index ,particle size, floating time production yield, drug loading efficiency ofmicrosponges and release profile in comparison with marketed drug.Results: Formulation F4 with a ratio 8:1 drug to polymer, and 0.25% polyvinylpyrrolodine solution was the best formulation showing the highest degree of sustainedrelease that was 79.59% at the end of 12 hours with a floating time capsule 12 hr.Eudragit RL 100 could control drug release in stomach.