Hepatoprotective activity of Artichoke (Cynara scolymus) against Paracetamol toxicity in female rats


Hepatotoxicity is an acute adverse effect of paracetamol overdose which could be fatal, so inthis research we studied the effect of paracetamol on liver enzymes (GPT, GOT, total protein,glucose, bilirubin) of female rats that drenched Artichoke. twenty laboratory female rats housed inplastic cages in animal house at university Karbala of / college of pharmacy , the animals dividedrandomly into four groups ,(G1 control, G2 drenched with 500 mg/kg Artichoke and 500 mg/kgparacetamol, G3 drenched with 500 mg/kg paracetamol ,G4 drenched with 500 mg/kg Artichoke ) ,the present study found the ability of Artichoke to protect liver enzyme against the poisonous effectof paracetamol by reducing the higher value of GPT,GOT, glucose, and evaluated the lower valueof bilirubin and total protein causing by paracetamol. Histopathological changes in liver weregreatly reduced on animals treated with artichoke and paracetamol when compared with theparacetamol group .However, animals treated with paracetamol showed severe congestion in centralvein and there is inflammatory cell and degeneration in hepatocyte enlargement in sensoides andnecrosis and odema.