EVALUATION OF SERUM OSTEOPONTIN LEVEL IN OBESE IRAQI POSTMENOPAUSAL WOMEN WITH PRIMARY OSTEOPOROSIS

Abstract

Background: Osteoporosis (OP) is a chronic and progressive disease characterized bydecreased bone mass and micro architectural deterioration of bone tissue, resulting in anincreased risk of fracture .Body mass index (BMI) has been found to be related to the risk ofosteoporotic fractures in women, regardless of bone mineral density (BMD). Very few studieshave investigated the comparison of fracture risk among BMI categories, classified accordingto the WHO criteria, despite the potential usefulness of such information for clinical purposes.Osteopontin was described as a major component protein in bone and named bonesialoprotein1 it’s produced by osteoblasts and osteoclasts. It has been found to be associatedwith bone strength and bone remodeling. OPN influences bone homeostasis both by inhibitingmineral deposition, by promoting differentiation of osteoclasts and by enhancing osteoclastactivity