Spectrophotometric determination of drug compounds in pure forms and in the pharmaceutical preparations


A sensitive, rapid and economical spectrophotometric processes for estimationof two drugs; methyldopa (MTD) and Fluvastatin Sodium (FLV), by “Sodium 1,2-naphthoquine- 4-sulfonate (NQS)” as reagent in an alkaline interemediate. Thesemethods are digested on the forming of “complexes” among these drugs and thechromogenic reagent (NQS). Orangish-brown colored complex formatted at (pH12) and λmax. 462 nm for (MTD), and orange colored at (pH 11.7) and λmax. 466 nmfor (FLV). Beer’s Law is obeyed in a concentrations range of (4-40 μg/mL), (16-64 μg/mL), with molar absorptivity (14.101×104 L/mol.cm), (22.7×104 L/mol.cm),and correlation coefficient 0.9995, 0.9987, successively, The detection limit andquantification limit were (1.03×10-1 μg/mL, 3.12×10-1 μg/mL ), and (1.36×10-1μg/mL, 4.12×10-1 μg/mL ), successively. The suggested methods were prosperityimplement to the estimation of “these drugs” in pure forms and in theirpharmaceutical formulations.