Studying of the physical and chemical characteristics for two formulations of Co-Trimoxazole and Trimethoprim oily injections


Over the past century there has been a dramatic increase in the utilization of the combination of Sulfamethoxazole (SMX) and Trimethoprim (TMP) solution as IV injection (Cotrimoxazole injection) as antibacterial agent in human and Trimethoprim Oily injection (IM) for sheep, goats . The aim of this study was to determine some physical and chemical properties for the above two formulations (appearance, pH, contents, sterility) as well as histopathological studying for trimethoprim oily injection in sheep,where both two formulations have pH = 9.8 , and the content of sulfamethoxazole and trimethoprim was 95.7% , 94.3% respectively for cotrimoxazole , while trimethoprim content in trimethoprim oily injection is 101% according to B.P. .