Synthesis, characterization and evaluation biological activity of new Schiff base compounds and their complexes with some transition elements

Abstract

The novel Schiff base ligand L1 (Z)-N'-(2-hydroxy-3-methoxybenzylidene)isonicotinohydrazide and L2 (Z)-N'-(2-hydroxy-3-methoxybenzylidene)nicotinohydrazide obtained by the condensation of isonicotinic hydrazide and benzahydrazide with o-Vanilin (2-hydroxy-3-methoxybenzaldehyde) and its Co(II), Ni(II) and Cd(II) complexes were synthesized and characterized by elemental analysis and various physico-chemical techniques like, FT-IR, 1H-NMR, Electrospray Ionisation mass(ESI-MS), UV-visible and molar conductance. The ligand involving oxygen atom of amide carbonyl, azomethine nitrogen and oxygen of hydroxyl via deprotonation. Spectral analysis indicates octahedral geometry for all the complexes. has 2:1 stoichiometry ratio of the type[M(L2)2Cl]. Schiff bases ligands and their complexes has been studied the biological activity where the schiff bases L1, L2 and their complexes showed lower efficiency than the standard inhibitor (Cipro.) trend three types of bacteria E-coli, salmonella spp. and staph. aureus, the prepared complexes appeared high effective than the effectiveness of the Schiff bases itself.