Outcome of Thymectomy in Patients with Generalized Myasthenia Gravis in Al-anbar Hospitals

Abstract

Background: Myasthenia Gravis (M.G) is well-known medical disease which needs good co-operation between physician and surgeon.Therapeutic varieties available include: - medical therapy with anti-cholinesterase medications ( and/ or)Immunosuppressant therapy, plasmapheresis, and surgical treatment by thymectomy.Objective: The aim of this study is to evaluate the outcome of the thymectomy in patients with generalized myasthenia gravis.Results: Eleven patients suffering from generalized myasthenia gravis of variable severity operated on, three males and 8 females, the age of patients were varied between (13 -58) years old.Majority of patients had thymic lymphoid follicular hyperplasia (eight patients) on post thymectomy histopathological examination for the removed thymus and adjacent mediastinal fat pad.One patient has myasthenic crisis and treated conservatively who was admitted to respiratory care unit under close observation and without the need for ventilator support for three days, no mortality reported in this study.All the rest ten patients did not need any post-operative ventilator support and they have uneventful post-operative period.Conclusions: Myasthenia gravis is not uncommon disease and require medical orientation and attention for the diagnosis.the pre-operative assessment and careful preparation can strongly affect the peri-operative and post-operative outcome.Early diagnosis of myasthenia gravis will affect the establishment of subsequent treatment option and early diagnosis caries better reliable management options.The delayed surgical removal treatment by thymectomy for generalized myasthenia gravis (MG) usually affects the prognosis of the disease worse.