Synthesis and Spectral Characterization of a New Series of N-4-Chlorobenzamide-5- phenylthiazolidin-3-one


A new series of 4-thiazolidinones (4a-j) has been synthesized by cyclocondensation of various acid hydrazones with thioglycolic acid. The intermediate hydrazones (3a-j) were synthesized by the condensation of various substituted benzaldehydes with 4-chlorobenzohydrazide (2). The starting compound 4-chlorobenzohydrazide was prepared from the reaction of ethyl 4-chlorobenzoate and hydrazine hydrate. The structures of the new synthesized compounds had been confirmed by spectral data (FTIR, 1H-NMR, 13C-NMR, and 13C-NMR –DEPT and ESIMS). Some of the synthesized compounds (4a-j) were evaluated for their antibacterial activity against Gram-positive bacteria staphylococcus aureus and Gram – negative psedomonas aeruginosa