A simple and Sensitive Spectrophotometric Method for the Determination of Trace Amounts of Sulfadiazine in Pharmaceutical Drugs Sample


This study includes a simple and sensitive spectrophotometric method for the estimation of trace amounts of sulfadiazine in aqueous solution utilizing oxidative coupling reaction of sulfadiazine with pyrocatechol in the existence of potassium periodate (KIO4) in acidic medium to yield a water-soluble dye which appear a maximum absorbance at 515 nm. The linearity is in the concentration range 0.2 - 20 μg/ml of SDZ, the molar absorptivity 1.2765× 104 liter. mol-1.cm-1 and the relative error ranges from 1.20 - 1.36 % depending on the concentration level of SDZ. The study was successfully applied to estimate the sulfadiazine in pharmaceutical drugs sample in the form of injections and burn cream.