Synthesis and Characterization of New Contact lenses Based on 2-Hydroxyethyl methacrylate

Abstract

In this present work describes the synthesis new soft contact lenses based on2-Hydroxy ethyl methacrylate monomer.2-Hydroxylethylmethacrylate (HEMA) waspolymerized by free radical polymerization in the presence of ethylene glycoldimethacrylate (EGDMA) as acrosslinker and Benzoyl peroxide as initiator. Thepolymerized materials were characterized fully for its use fullness as an intraocularlens by various techniques. FTIR and 1HNMR were performed to find out the totalconversion of monomer 2-Hydroxylethyl methacrylate into hydrogels contact lens.The hydrogels contact lenses were manufactured from different materials, thesematerials and water content were: copolymerization 2-Hydroxylethyl methacrylatewith methacrylic acid (77.1%), Chitosan 82%, Methylacrylate 54%, Ethylhexylmethacrylate 56%.The equilibrium water content (EWC) was measured for all thehydrogels at 34°C and it was observed that the hydrophilic hydrogels swelling morethan hydrophobic hydrogels. The oxygen permeability (DK) was measured byMorgan & Efron equation, the results show, the hydrophilic hydrogels display higheroxygen permeability towards the cornea more than hydrophobic hydrogels. Theamount of proteins adsorbed on the membrane surface of hydrogels contact lenseswas calculated from the concentration of proteins in the SDS solution using a BCAprotein assay reagent kit. The results show albumin deposits in higher concentrationson hydrophobic surfaces, as compared to relatively hydrophilic surfaces.Thetransparency of all hydrogels were examined by using UV-visible spectrophotometer.The results show that all hydrogels contact lenses allowed range of lighttransmittance 58-94% ,at wave lengths between 400-700nm.Keywords:Hydrogels;Contact lenses;Protien adsorption ;Oxygen Permability