pEffect of Synthesized Oxiranes and Pyrrolidines on KMP II and LPG 3 genes in Leishmania infantum Promastigotes

Abstract

The research includes synthesis of some heterocycles: oxiranes (O1-O3) through the reaction of chalcones with hydrogen peroxide, and pyrrolidines (P1-P3) by the condensation of chalcones with Schiff bases. The structures of these synthesized heterocycles had been supported by spectral data (1HNMR, IR, UV) and observed their effect on KMP II and LPG 3 genes. The results showed that some compounds gave genetic heterogeneity in these genes suggesting that it could be a good target for treatment of L. infantum.