The Effect of Iron Overload on Histological Picture in Testis of Mature Male Rats


This study was designed to determine the effect of ferrous sulfate (100mg / kg b. w) on histopathological picture of the testis in male rats. Twelve white adults male rat were used and divided into two groups, first group was included (6) males were given ferrous sulfate solution daily by mouth for a period of (60) days, and the second group included (6) males which were treated under normal conditions consider as a control group. The results showed that the treated group with iron caused a significant decrease (P <0.05) in the weight of each testis, prostate and seminal vesicle compared with the control group. The study was indicated that treatment with iron caused a significant decrease (P <0.05) in the spermatic tubule diameters and thickness of the seminiferous tubule epithelium compared with the control group. The histological study also was showed that pathological changes in the testes of treated group with iron which included necrosis and degenerative changes. The conclusion from this study demonstrated that the iron caused adverse effects on the histological pictures which considered a perfect indicator in that iron caused stress and a negative factor if it exceeds the normal level.