Effect of Bisphenol-A- on Some Biochemical and Hematological Parameters of Female Rats(Rattus Norvegicus)

Abstract

Bisphenol A (BPA) is one of the manufacturing compounds. The presentstudy was conducted to investigate effect of BPA on some biochemical andhematological parameters such as Alanine Aminotransferase (ALT), AspartateAminotransferase(AST) Glucose, Red blood cells (RBCs), Hemoglobin (Hb),White blood cells (WBCs) and differential WBCs. Twenty four female rats wereused and divided into three groups (8 animals for each group) randomly. Animalsof first group was negative control group and second group was positive controlgroup received normal saline and corn oil orally respectively,while female rat ofthird group were received BPA suspended with corn oil (250mg/kg B.W/day) orallyas treatment group for 30 days . Results of the present study revealedsignificantincrease (P≤0.05) in serum level of ALT, AST, Glucose, WBCs counts andpercentage of neutrophil but there is significant decrease (P≤0.05) in RBCs counts,Hb concentration and percentage of lymphocyte in group administrated BPA incompared with control groups,while there are non significant changes in percentageof monocyte, eosinophil and basophilFrom the results of the present study, itwas concluded thatBPA leads to occurred negative results on hematological andbiochemical parameters.

Keywords

Bisphenol-A-, ALT, AST, Rat.