Evaluation of Thyroid Function in Sera of Acute and Chronic Leukemic Patients

Abstract

AbstractBackground: This study aims to compare thyroid function between patients with acute and chronic leukemia, through measurement of triiodothyronin, tetraiodothyronin (thyroxin), free triiodothyronin, free tetraiodothyronin, thyroid stimulating hormone, antithyroglobulin, and antithyroperoxidase . Material and Methods: One hundred twenty subjects collected from the Hematological Center / AL-Mustansiriya University, This subjects divided into two groups depending on the lineage of the original mutated cell: forty patients of chronic lymphocytic leukemia and forty patients of acute lymphocytic leukemia and forty healthy control for comparison with two groups. Complete blood count of each subjects was evaluate by using Hemolyzer 5 instrument, and Hormonal tests which include: triiodothyronin, tetraiodothyronin (thyroxin), free triiodothyronin, free tetraiodothyronin, thyroid stimulating hormone, were measured by using Minividas. antithyroperoxidase and antithyroglobulin were measured by using Enzyme Linked immunosorbent assay. Result: The result indicated a presence of highly significant increase (P<0.001) of red blood cell and platelet among patients with acute lymphocytic leukemia when compared with control groups, while highly significant decreased (P<0.001) of red blood cell in chronic lymphocytic leukemia when compared with control groups and highly significant increase (P<0.001) of platelets were found in chronic lymphocytic leukemia when compared with control groups. A significant increase (P<0.05) of thyroid stimulating hormone, free triiodothyronin, antithyroglobulin, and antithyroperoxidase in sera of both acute lymphocytic leukemia and chronic lymphocytic leukemia patients in comparison to that of the control group. A significant positive correlation (p˂0.05) was observed between antithyroperoxidase and free tetraiodothyronin in sera of acute lymphocytic leukemia patient while, in contrast with chronic lymphocytic leukemia group there was no significant correlation. A significant negative correlation (p˂0.05) between antithyroperoxidase and RBC was observed , while a significant positive correlation (p˂0.05) between antithyroperoxidase with platelet was observed in sera of chronic lymphocytic leukemia patient.Conclusion: Increase of antithyroglobulin, and antithyroperoxidase with the increase of thyroid stimulating hormone levels of both groups (acute lymphocytic leukemia and chronic lymphocytic leukemia) indicate an autoimmune thyroid disorder, and the free tetraiodothyronin is an important test and it may be used with antithyroperoxidase as a marker for diagnosis of leukemia.