Antibacterial effect of grape seeds polyphenols against Salmonella Typhimurium infection in mice

Abstract

Infection with Salmonella Typhimurium causes systemic infection and gastroenteritis in human and animals. Polyphenols especially in grape seeds have immunomodulation anti-inflammatory effects and antimicrobial activities. The current study was designed to investigate the antibacterial activity of GSP on the amelioration of liver and intestinal tissues inflammation and cell apoptosis induced by S. Typhimurium in infected mice. The parameters which were used in this study, including that determention the histopathological changes in liver and intestinal paraffin embedded block tissue and cells apoptosis that confirmed by using Dead End™ Fluorometric (TUNEL System). The histopathological changes in the liver and intestinal tissues showed less changes with potent inflammatory response in the treated groups, that lead to the decreasing of pathological sings in liver and intestinal tissue and showed lower apoptotic activity