Evaluation the relationship between the antibodies of Helicobacter pylori and Interleukin-6 in patients with gastritis in Kirkuk province


Background:: Helicobacter pylori is recognized as the most common cause of chronіc gastrіtis, and also an important pathogenic factor in peptic ulcer disease, after colonization and persistant in the mucus layers of the human stomach causes a raised level of pro-inflammatory cytokine such as IL-6.Materials and Methods: The study was conducted in Kirkuk city from 15th of December 2016 to 15th of June 2017 in Azady teaching hospital in Kirkuk governorate, anti H. pylori IgG level and IL-6 level were estimated by using anti H. pylori IgG ELISA kit and IL-6 ELISA kit.Results: A total of 90 patients the interleukin-6 level and anti H. pylori IgG level in a group of untreated patients against H. pylori infection (225.592 ng/L, 1.338 pg/ml respectively) and in a group of patients who had previously treated against H. pylori infection (102.60 ng/L, 0.350 pg/ml respectively) were significantly higher as compared to those of the control group (55.91 ng/L, 0.250 pg/ml respectively).Conclusion: There were a positive correlation between specific anti H. pylori IgG level and IL-6 level in H. pylori associated with gastric ulcer diseases.